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A patient with scleroderma has normal lung volumes but low DLCO of 40 percent. There is minimal fibrosis on HRCT. You suspect the patient may have pulmonary hypertension.
What is the next best investigation?
Which of the following medication is helpful for scleroderma associated interstitial lung disease, especially when the FVC is less than 70% and the extent of fibrosis on HRCT is above 20 percent?
A patient with scleroderma undergoes a screening ECHO and is found to have a systolic pulmonary artery pressure of more than 50mmHg.
What should be the next step in management?
The following treatments are most useful in pulmonary hypertension associated with Systemic sclerosis except?
The following are associated with scleroderma renal crisis except?
What is the medication of choice for the treatment of scleroderma renal crisis?
Which of the following medication is least useful in the treatment of Raynaud’s?
Which of the following clinical feature is no longer used to define rheumatoid arthritis?
All of the following joint may be affected by rheumatoid arthritis (RA) except?
What is the typical number of WCC (In cells/mm 3) and PMNs seen in the synovial fluid taken from a patient with rheumatoid arthritis?
A 55 year old lady with a known history of rheumatoid arthritis is found to have splenomegaly on abdominal examination. Which of the following feature would most likely suggest the diagnosis of Felty’s syndrome?
A 45 year old lady with a background of Hepatitis C infection presents to the clinic with a 3 months history of joint pain on both her hands. The pain specifically involves her distal interphalangeal joints. Earlier in the month, the GP had requested a blood test for rheumatoid factor and the result came back positive with very high titres.
What would be the most likely explanation for the rheumatoid factor positivity?
Rheumatoid factor positivity can be seen in all of the following conditions except?
Which of the following marker is most specific for rheumatoid arthritis?
The following are poor prognostic markers in RA except?
Which of the following radiologic features is not typical of RA?
You are doing an annual review of a 50-year-old woman with rheumatoid arthritis.
Which of the following complications is most likely to occur as a result of her disease?
Which of the following marker is most predictive of subsequent death from cardiovascular disease in patients with rheumatoid arthritis?
A 42-year-old female with rheumatoid arthritis still has severe joint pains despite being on 3 DMARDs (prednisone, methotrexate and sulfasalazine) and leflunomide for 6 months.
What should be the next step in management?
A 52-year-old female with known rheumatoid arthritis has been clinically well controlled on a combination treatment of prednisone and methotrexate for many years. However, the last 2 days, she has had a flare up of her RA.
What is the most appropriate step in management?
Which of the following DMARDs is least likely to slow the radiographic progression of RA?
A 30-year-old female with RA has been on a particular DMARDs for the last 5 years with good symptom control.
Unfortunately, she has now developed reduced visual acuity.
Which of the following is likely the culprit drug?
You are considering starting DMARDs on a patient with RA who is known to be a heavy drinker.
Which would be the best choice of treatment for this patient?
Which one of the following cytokines is the most important in the pathophysiology of rheumatoid arthritis?
A patient on leflunomide for his RA develops severe liver damage and myelosuppression.
What should be the most appropriate management?
Which of the following drug is not known to be a Tumor Necrosis Factor inhibitor (TNF-inhibitor)?
Which of the following drug is associated with increased risk of reactivation of latent TB?
The following are side effects of TNF inhibitors except?
What is the mechanism of action of Abatacept?
Which of the following statements regarding the use of JAK inhibitors in the treatment of Rheumatoid Arthritis (RA) is correct?