Copy of Immunology Module 1

Lymph nodes are the major site for interaction between antigen presenting cells and:

In which of the following does mannose binding lectin (MBL) have the most significant role?

A deficiency in the following complement/s would usually predispose a patient to disseminated meningococcal infection:

Which of the following exposure poses the highest risk of HIV transmission?

Entry of HIV into host cell occurs via which protein?

All of the following statements are true regarding the R5 Strain of the human immunodeficiency virus except?

All of the following statements are true regarding HIV-2 except?

Which of the following features would be highly suggestive of an acute HIV-1 infection?

During an acute infection with a virus, which of the following is the most important antigen-specific immune response that eradicates viruses from the body?

A 30 year old man presents with symptoms of fever, sore throat,headache, myalgia and diarrhea 3 weeks after returning from Thailand.

On examination there is fever T: 38.pharyngeal edema and hyperemia and sharply demarcated ulcers found on the oral mucosa.

Lab test shows moderate neutropenia, thrombocytopenia, mild anemia and lymphopenia with atypical lymphocytes(mostly CD8 cells).

Raised ALT and AST.

What is the most likely diagnosis?

A 16 year old girl recently had unprotected sex with a man known to be HIV positive.Which of the following tests is most helpful in establishing whether she has been infected with HIV?

Which of the following is the most powerful predictor of progression to AIDS?

Which of the following is the strongest single predictive marker of disease progression at all stages of HIV?

In chronic granulomatous disease, the mechanism of abnormal phagocytic cell function is:

Which of the following ART has been implicated in the development of lipodystrophy(buffalo hump) in HIV patients.

Which of the following ART causes pancreatitis?

Which of the following ART causes peripheral neuropathy?

Which of the following ART causes renal colic?

What is the mechanism of Type 4 hypersensitivity?

Which of the following ART should be avoided in pregnancy?

A 25 year old mother has a 6 year old son and both of them are HIV positive.She is pregnant and asks you what the chances of her baby developing HIV if she takes her ART during pregnancy?

The following are associated with increased risk of HIV transmission except?

In a HIV patient, all of the following complications may only develop once the CD4 count drops to less than 200, except?

What is the effect of being Heterozygous for CCR5 Delta 32 allele in the development of HIV and AIDS?

A patient with HIV on ART for 10 years with stable CD4 count and undetectable viral load asks if he could stop taking ART.

What should you advice?

A patient with HIV is found to have HLA-B5701 genotype on pharmacogenetic testing .With regards to initiation of HAART, which medication should be avoided?

Which of the following ART is associated with increased risk of myocardial infarction?

What is the mechanism of action of Raltegravir?

Which of the following ART causes indirect hyperbilirubinemia?

A patient with HIV treated with Ritonavir(protease inhibitor) develops lipodystrophy.

He is treated with lovastatin as part of the management for his lipodystrophy.

What complication might arise from this treatment?