Copy of Immunology Module 1

In patients with HIV,which of the following opportunistic infection occurs at all CD4 cell counts?

Lymph nodes are the major site for interaction between antigen presenting cells and:

What is the approximate half-life of serum immunoglobulin M (IgM)?

In which of the following does mannose binding lectin (MBL) have the most significant role?

Which immunoglobulin in human breast milk is the most immunoprotective?

A deficiency in the following complement/s would usually predispose a patient to disseminated meningococcal infection:

Cytokine regulation (especially involving interleukin 2) is least affected by which one of the following immunosuppressive drugs?

A type 2 helper T lymphocyte (Th2 cell) differs most from a type 1 helper T lymphocyte (Th1 cell) in which one of the following?

Entry of HIV into host cell occurs via which protein?

Peptides derived from degraded intracellular proteins will bind to which molecule?

All of the following statements are true regarding the R5 Strain of the human immunodeficiency virus except?

Four cytokines produced by T cells are listed:

• interleukin 2 (IL-2)
• interleukin 4 (IL-4)
• interleukin 5 (IL-5)
• interferon gamma (IFNγ)

Which combination would best reflect a Th2 type T cell immune response?

Secretion of which of the following cytokines is most characteristic of T helper cells from patients with cell-mediated immune disorders such as multiple sclerosis?

During an acute infection with a virus, which of the following is the most important antigen-specific immune response that eradicates viruses from the body?

Memory T lymphocytes differ most from naive T lymphocytes with respect to:

A 30-year-old man presents with a 3-week history of fever, sore throat, headache, myalgia, and diarrhea following a trip to Thailand.

On examination, he has a fever of 38°C, pharyngeal edema, hyperemia, and sharply demarcated ulcers on the oral mucosa. Laboratory tests reveal moderate neutropenia, thrombocytopenia, mild anemia, lymphopenia with atypical lymphocytes (predominantly CD8 cells), and elevated liver enzymes (ALT and AST).

What is the most likely diagnosis?

A T lymphocyte encountering its specific antigen in the absence of a co-stimulatory signal via CD28 is least likely to:

T lymphocytes expressing both CD4 and CD8 on the cell surface are most likely to be found in which one of the following anatomical locations in healthy individuals?

Which of the following is the most common clinical picture associated with Immunoglobulin G (IgG) subclass deficiency?

Which of the following is the most powerful predictor of progression to AIDS?

Which immunological mechanism is the major cause of the destruction of the small intestinal villous architecture in coeliac disease?

In chronic granulomatous disease, the mechanism of abnormal phagocytic cell function is:

The cell population most responsible for driving the pathogenesis of sarcoidosis is:

Secretion of which of the following cytokines is most characteristic of CD4+CD25+ regulatory T lymphocytes (Tregs) in downregulation of immune responses?

Which of the following ART causes pancreatitis?

A mutation in the FOXP3 gene will most likely cause which of the following disorder?

What is the mechanism of Type 4 hypersensitivity?

Which of the following cytokine causes T-cell proliferation?

The cell type that plays a predominant role in the early inflammatory phase of an IgE mediated allergic response is the:

Which of the following ART is associated with increased risk of myocardial infarction?

What is the mechanism of action of Raltegravir?

Which of the following is a major immunological abnormality in advanced HIV infection?