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A 72-year-old man is referred to haematology with a raised haemoglobin. A diagnosis of polycythaemia rubra vera is suspected. Which other abnormality of the blood would be most consistent with this diagnosis?
Which one of the following therapeutic options is least recognised in the treatment of aplastic anaemia?
Which one of the following haematological malignancies is most commonly associated with the t(11;14) translocation?
A 15-year-old girl is referred to haematology. She started having periods three years ago which have always been heavy and prolonged. Unfortunately the menorrhagia has responded poorly to trials of tranexamic acid and the combined oral contraceptive pill. Blood tests show the following:
|Plt||239 x 109/l|
|WBC||6.5 x 109/l|
What is the most likely diagnosis?
Which one of the following is least recognised as a treatment modality in idiopathic thrombocytopenic purpura?
Which of the following drug is known to cause a rapid onset of drug induced immune thrombocytopenia?
An 80-year-old man is reviewed in the haematology clinic. He has been referred due to weight loss, lethargy and a significantly elevated IgM level. Recent bloods show the following:
|Platelets||127 x 109/l|
|IgM||2150 mg/dl (range 50-330 mg/dl)|
Given the likely diagnosis, which one of the following complications is he most likely to develop?
A 28-year-old man is investigated for cervical lymphadenopathy. A biopsy shows nodular sclerosing Hodgkin’s lymphoma. Which one of the following factors is associated with a poor prognosis?
A 24-year-old man is diagnosed with a deep vein thrombosis of his right leg. He is initially treated with lowmolecular weight heparin but is switched after three days to warfarin. He then develops necrotic skin lesions on his lower limbs and forearms. Which one of the following conditions is characteristically associated with this complication?
In idiopathic thrombocytopenic purpura what are the autoantibodies most commonly directed at?
A 34-year-old man who is known to have type 1 von Willebrand’s disease asks for advice. He is due to have a tooth extracted at the dentist next week. Which one of the following is the most appropriate management to reduce the risk of bleeding?
A 66-year-old woman is referred by her GP with anaemia. She has been feeling generally unwell for the past 3 weeks. Bloods on admission show:
|Plt||198 x 109/l|
|WBC||5.3 x 109/l|
Further tests were then ordered:
|Direct antiglobulin test||Positive, IgG only|
|Film||Marked red cell agglutination at room temperature|
Which one of the following is the most likely underlying cause?
A 17-year-old man is investigated after he bled excessively following a tooth extraction. The following results are obtained:
|Plt||173 x 109/l|
Which clotting factor is he most likely to be deficient in?
Of the following options, which one is the best diagnostic test for paroxysmal nocturnal haemoglobinuria?
A 25-year-old woman with primary antiphospholipid syndrome is reviewed. She has just had a booking ultrasound at 11 weeks gestation which confirms a viable pregnancy. This is her first pregnancy and she is otherwise fit and well. Which one of the following is the recommend treatment?
Transmission of which type of infection is most likely to occur following a platelet transfusion?
Patients with Sjogren’s syndrome are at an increased risk of which one of the following malignancies?
Burkitt’s lymphoma is associated with which one of the following genetic changes:
Which one of the following is the most common inherited thrombophilia?
Each one of the following is associated with polycythaemia vera, except:
A 4-year-old girl with sickle cell anaemia presents with abdominal pain. On examination she is noted to have splenomegaly and is clinically anaemic. What is the most likely diagnosis?
Which one of the following statements regarding heparin-induced thrombocytopaenia (HIT) is correct?
Which one of the following features is least associated with Waldenstrom’s macroglobulinaemia?
Interferon alpha is a recognised treatment for which one of the following haematological disorders?
A 17-year-old male is diagnosed with alpha-thalassaemia.
What chromosome is the alpha-globulin genes located on?
A 72-year-old woman is admitted with confusion and pallor. Her daughter reports that she has been getting more confused are tired for the past three months. Blood tests are reported as follows:
|Plt||148 x 109/l|
|WBC||4.4 x 109/l|
In light of the macrocytic anaemia some further tests are ordered:
|Intrinsic factor antibodies||Negative|
|Vitamin B12||94 ng/l (200-900 ng/l)|
|Folic acid||1.1 nmol/l (> 3.0 nmol/l)|
What is the most appropriate management?
Which one of the following is associated with a high leucocyte alkaline phosphatase score?
Which one of the following statements regarding warfarin is correct?
Which one of the following feature confirms the presence of CML?
A 72-year-old woman is found to have a marked lymphocytosis associated with smudge cells on the blood film. A diagnosis of chronic lymphocytic leukaemia is suspected. Which one of the following is the investigation of choice?