Copy of Haematology Module 5

Which one of the following features is least recognised in thrombotic thrombocytopenic purpura?

Which one of the following would most suggest a leukaemoid reaction rather than chronic myeloid leukaemia?

A 62-year-old man presents with lethargy. A full blood count is taken and is reported as follows:

What is the most likely diagnosis?

A 24-year-old nulliparous female with a history of recurrent deep vein thrombosis presents with shortness of breath. The full blood count and clotting screen reveals the following results:

What is the most likely underlying diagnosis?

A 73-year-old man is prescribed cetuximab after being diagnosed with metastatic colorectal cancer. What target is this monoclonal antibody directed against?

A 34-year-old female develops a purpuric rash on the back of her legs. Her only regular medication is Microgynon 30. She also reports frequent nose bleeds and menorrhagia. A full blood count is requested:

What is the most likely diagnosis?

A 26-year-old man with a history of hereditary haemorrhagic telangiectasia is planning to start a family. What is the mode of inheritance?

A man is investigated for anaemia. A blood film is ordered and reported as follows:

Ring sideroblasts

Which one of the following is least likely to give this picture?

A 35-year-old woman presents with menorrhagia and a persistent sore throat. A full blood count shows the following:

Which medication may have caused this?

A 35-year-old female who is 34 weeks pregnant presents with a swollen, painful right calf. A deep vein thrombosis is confirmed on Doppler scan. What is the preferred anticoagulant?

A 67-year-old woman is referred to the haematology clinic. Her GP has noted that her platelet count is persistently elevated and no reactive cause can be found. Bloods taken a week before clinic are as follows:

What is the treatment of choice?

A 74-year-old woman with a past history of chronic lymphocytic leukaemia presents with lethargy. The following blood results are obtained:

Which complication most likely occurred?

A 31-year-old man is referred to the acute medical unit with a painful swollen left leg. The patient reports that he has the ‘Factor V Leiden mutation’. Which one of the following best describes the pathophysiology of his condition?

A 31-year-old woman who is 25-weeks pregnant is brought to the Emergency Department by her husband. Over the past two days she has become increasingly confused. Her temperature is 37.8ºC and blood pressure is 104/62 mmHg. Blood tests show:

What is the most appropriate treatment?

What is the most common inherited bleeding disorder?

Which one of the following is the most common type of Hodgkin’s lymphoma?

A 45-year-old man known to have haemochromatosis attends for blood test to assess when he next needs venesection. Of the options given, which one of the following blood tests should be used to assess the adequacy of venesection?

A 64-year-old man is reviewed in the haematology clinic. Which one of the following features would suggest that a diagnosis monoclonal gammopathy of undetermined significance is more likely than myeloma?

Regarding the Ann-Arbor classification of Hodgkin’s lymphoma, which one of the following would be staged as IIIB?

What are the most common types of transformations seen in patients with polycythaemia rubra vera?

Each one of the following is associated with iron-deficiency anaemia, except:

Burkitt’s lymphoma is associated with a mutation in which one of the following genes?

A 18-year-old man who is known to have hereditary spherocytosis is admitted to hospital with lethargy. Admission bloods show the following:

What is the most likely explanation for these findings?

A 23-year-old woman presents with lethargy. There is no history of bleeding. The following blood results are obtained:

What is the most likely diagnosis?

A 30-year-old man enquires about screening for haemochromatosis as his brother was diagnosed with the condition 2 years ago. The patient is currently well with no features suggestive of haemochromatosis. What is the most appropriate investigation?

You review a 61-year-old woman with end stage kidney failure. Four months ago she developed a deep vein thrombosis and was warfarinised with a target INR of 2.5.

She now presents with a swollen, tender left calf and Doppler scan confirms a further deep vein thrombosis. Her INR has been above 2.0 for the past three months.

What should happen in regards to her anti-coagulation?

Which one of the following is least associated with thrombocytopenia?

Which one of the following is least associated with eosinophilia?

Each one of the following is associated with hyposplenism, except:

The following intervention is useful in the management of diffuse large B-cell lymphoma except?