Copy of Haematology Module 1

Which one of the following cytogenetic abnormality has the best prognosis in Acute myelogenous leukemia?

AML outcomes are strongly related to which factor?

A 54-year-old man is diagnosed as having acute myeloid leukaemia. What is the single most important test in determining his prognosis?

Which of the following factors is associated with a good prognosis in acute myeloid leukaemia?

A 48-year-old man is diagnosed with acute myeloid leukaemia and cytogenics are performed. Which one of the following is associated most with a poor prognosis?

Which one of the following mutation is the most commonest genetic abnormality in AML?

A surgical registrar rings you for an opinion regarding bridging anticoagulation therapy for a patient with atrial fibrillation (CHADS2 score of 2) who is about to undergo an elective bowel surgery tomorrow. The patient’s warfarin has been withheld for 5 days. What would you advise them to do?

Which of the following chemotherapeutic agent is least likely to be beneficial in the treatment of AML?

Which one of the following translocations is associated with acute promyelocytic leukaemia?

A 36 year old patient with acute promyelocytic leukemia (APML) develops symptoms of cough,dyspnea, fever, weight gain and edema 10 days after commencing ATRA. Further imaging reveals pleural and pericardial effusion and pulmonary infiltrates.Serial blood test shows progressive renal failure. Clinically the patient is in severe respiratory distress with severe hypoxemia.

What is the most appropriate next step in management?

Which one of the following is not an indication for treatment in chronic lymphocytic leukaemia?

A 65-year-old woman is reviewed. She is on the waiting list for a varicose vein operation but during the preoperative assessment was noted to have a raised lymphocyte count. She reports feeling well currently and clinical examination is normal. Her bloods were as follows:

Hb 118 g/l
Plt 184 (10⁹/l)
WBC 21.2 (10⁹/l)

There are no previous bloods to compare these results with. Following referral to haematology a diagnosis of chronic lymphocytic leukaemia was made. What is the most appropriate management?

A 71-year-old woman with no significant past medical history is investigated for lymphocytosis. She has recently lost 7kg in weight and complains of lethargy. The following blood results are obtained:

Four months previously her white cell count was 30.5 (10⁹/l). 

Cytogenetics: TP53 mutation is not present and IGHV is mutated.

What is the most appropriate management?

A 77-year-old man with a history of chronic lymphocytic leukaemia is admitted to the Acute Medical Unit with pneumonia. This is his fourth admission for pneumonia in the past six months. Which one of the following factors is most likely to be responsible?

Which of the following is a good prognostic factor in chronic lymphocytic leukaemia?

Venetoclax has recently been proven to be useful in the treatment of which condition?

Ibrutinib has a role in the treatment of all the following types of malignancy except?

Most cases of CML is detected in which decade of life?

A 52-year-old is found to have chronic myeloid leukaemia following investigation for splenomegaly. Which one of the following best describes the function of the BCR-ABL fusion protein?

A 52-year-old man with a history of anaemia and abdominal discomfort is diagnosed as having chronic myeloid leukaemia. What is the mechanism of action of imatinib?

A 50-year-old woman is investigated for weight loss and anaemia. She has no past medical history of note. Clinical examination reveals splenomegaly associated with pale conjunctivae. A full blood count is reported as follows:

Given the likely diagnosis, what is the most appropriate treatment?

The following are appropriate therapy for chronic phase of CML except?

A patient with myelodysplasia is at risk of transformation into which type of malignancy?

The following are poor prognostic factors for ALL except?

Which of the following treatment is effective for Philadelphia positive ALL?

Which of the following agent is most effective in the treatment of myelodysplastic syndrome with chromosome 5q syndrome?

Which of the following is not a parameter for assigning risk score in CML?

The following features suggest a complete hematological response following treatment for chronic myeloid leukemia (CML), except?

The following are known side effects of Tyrosine kinase inhibitor,  Imatinib except?

What is the main mechanism of imatinib resistance in CML?

Which one is the main transporter of Imatinib?

A 45 year old man with Philadelphia chromosome positive acute lymphocytic leukemia(ALL) develops severe GI toxicity and fluid retention after using Imatinib.

What is the next appropriate step in management?

At the time multiple myeloma is diagnosed, what is the most common presentation?

All of the following intervention are appropriate for patients who are deemed to have lower-risk myelodysplastic syndrome (MDS) except?