Copy of Haematology Module 1

Which one of the following cytogenetic abnormality has the best prognosis in Acute myelogenous leukemia?

Clinical outcomes from acute myeloid leukemia is strongly related to which factor?

A 54-year-old man is diagnosed as having acute myeloid leukaemia. What is the single most important test in determining his prognosis?

A 36 year old patient with acute promyelocytic leukemia (APML) develops symptoms of cough,dyspnea, fever, weight gain and edema 10 days after commencing ATRA. Further imaging reveals pleural and pericardial effusion and pulmonary infiltrates.Serial blood test shows progressive renal failure. Clinically the patient is in severe respiratory distress with severe hypoxemia.

What is the most appropriate next step in management?

Which of the following chemotherapeutic agent is least likely to be beneficial in the treatment of AML?

Which one of the following is not an indication for treatment in chronic lymphocytic leukaemia?

A 65-year-old woman is reviewed. She is on the waiting list for a varicose vein operation but during the preoperative assessment was noted to have a raised lymphocyte count. She reports feeling well currently and clinical examination is normal. Her bloods were as follows:

Hb 118 g/l
Plt 184 (10⁹/l)
WBC 21.2 (10⁹/l)

There are no previous bloods to compare these results with. Following referral to haematology a diagnosis of chronic lymphocytic leukaemia was made. What is the most appropriate management?

A 71-year-old woman with no significant past medical history is investigated for lymphocytosis. She has recently lost 7kg in weight and complains of lethargy. The following blood results are obtained:

Four months previously her white cell count was 30.5 (10⁹/l). 

Cytogenetics: TP53 mutation is not present and IGHV is mutated.

What is the most appropriate management?

A 77-year-old man with a history of chronic lymphocytic leukaemia is admitted to the Acute Medical Unit with pneumonia. This is his fourth admission for pneumonia in the past six months. Which one of the following factors is most likely to be responsible?

Venetoclax has recently been proven to be useful in the treatment of which condition?

Ibrutinib has a role in the treatment of all the following types of malignancy except?

A 52-year-old man with a history of anaemia and abdominal discomfort is diagnosed as having chronic myeloid leukaemia. He is commenced on imatinib.

What is the mechanism of action of imatinib?

A 45 year old man with Philadelphia chromosome positive acute lymphocytic leukemia(ALL) develops severe GI toxicity and fluid retention after using Imatinib.

What is the next appropriate step in management?

The following are appropriate therapy for chronic phase of CML except?

A patient with myelodysplasia is at risk of transformation into which type of malignancy?

The following are poor prognostic factors for ALL except?

Which of the following treatment is most effective in physically fit patients with previously untreated chronic lymphocytic leukemia (CLL)?