Copy of Endocrinology Module 6

A 40 year old man develops sudden onset of severe frontal headache, diplopia associated with nausea and vomiting.

Examination reveals CN III palsy and bitemporal hemianopia.

MRI shows pituitary apoplexy.

What is the most appropriate next step?

A 37 year old patient with schizophrenia on olanzapine complaint of muscle ache.Prolatin levels are 870 and 980 (normal 60-600) on two separate occasions.He is on no other medication.

Examination reveals mild gynaecomastia.no galactorrhea. virilisation and testicular size normal.  There are no signs of hypothyroidism.

What is the next step in management?

The following sign is most specific for Cushing’s syndrome:

Which feature is most specific for Cushing’s disease?

A 30 year old woman treated with cabergoline 0.5mg weekly for amenorrhea secondary to a 4mm prolactinoma.

She consults you two weeks after recording a positive pregnancy test.

The most appropriate management is to:

Which condition causes a predominant increase in LDL-cholesterol?

Which medication should you avoid when managing a thyroid storm?

Carbimazole inhibits which pathway?

A 20 year old male patient with Type 1 diabetes on insulin pump presents with mild DKA with pH of 7.2 and BSL of 17.

What is the most appropriate initial intervention?

The presence of multifocal subperiosteal bone resorption, is most specific for which condition?

An 85-year-old man from rest home with a background of type 2 diabetes presents to the emergency department with decreased level of consciousness. It seems that for the last 3 days, he has had watery diarrhea with six to ten bowel movements per day.

After looking at his medication list from the rest home, it appeared that this man had not taken his insulin for the past 3 days.

On examination, he is afebrile and clinically dehydrated.

• serum blood glucose level is 25
• serum sodium 150
• serum potassium 5.1
• serum Cr 280
• serum Urea 42
• plasma osmolality 375

You decide to administer IV Insulin for this man.

Which set of electrolytes are most likely to change after intravenous insulin is administered?

Which medication is not helpful in preventing post-menopausal osteoporosis?

The most potent biphosphonate is?

What is the BMI threshold for recommending metabolic surgery in caucasian patients with Type 2 diabetes regardless of their glycemic control?

Romosozumab is a novel monoclonal antibody used in preventing fracture in women with osteoporosis.

It works by binding against which protein?